- RetroVirox has launched a menu of cell-based antiviral services.
- They will be used for experimental therapies and vaccines against coronaviruses.
- The assay utilizes pseudoviruses coated with the viral spike (S) protein of SARS-CoV-2.
- It will recapitulate the mode of entry of the novel coronavirus.
According to an article published in Virus World, RetroVirox has launched a menu of cell-based antiviral services to evaluate experimental therapies and vaccines against coronaviruses, including SARS-CoV-2.
In vitro testing with SARS-CoV-2
Starting today the company will offer in vitro testing with SARS-CoV-2 pseudoviruses to evaluate entry inhibitors against the novel coronavirus causative agent of COVID-19. The assay utilizes pseudoviruses coated with the viral spike (S) protein of SARS-CoV-2 to recapitulate the mode of entry of the novel coronavirus.
Uses of assay
The assay can be used for the following purposes:
- To determine the neutralizing activity of therapeutic antibodies and antisera
- To test experimental COVID-19 vaccines using antisera from inoculated animals or humans
- To evaluate small-molecule and other entry inhibitors targeting the S viral protein, the ACE-2 viral receptor, or host proteases and other targets involved in SARS-CoV-2 viral entry
RetroVirox also performs in vitro assay against several milder forms of seasonal human coronaviruses (hCoV), including the strains OC43, and 229E.
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Source: VirusWorld
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