New Study Differentiates Long-COVID And Other Post-Viral Infections

203

  • Researchers reviewed the symptoms, illness duration, long-term clinical traits, and possible healthcare burden of post-viral conditions in children and adolescents under 20 years.
  • Researchers evaluated the effects of post-acute infection syndromes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • The study reported both physical and psychological symptoms, with similar symptom duration for post-COVID-19 and post-EBV/gastrointestinal virus syndromes.

In a recent review published in eClinicalMedicine, researchers reviewed the symptoms, illness duration, long-term clinical traits, and possible healthcare burden of post-viral conditions in children and adolescents under 20 years, reports News Medical.

Specifically, they evaluated the effects of post-acute infection syndromes due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), otherwise known as Long COVID (coronavirus disease 2019/COVID-19) and other viruses that infect children, such as Varicella, Influenza, Epstein–Barr virus (EBV), Ebola, etc.

Background

Even though viral infections are common in children, children do not typically suffer from severe disease. However, post-viral infection syndromes sharing common etiopathogenesis, irrespective of the causal pathogen, occur in children and adolescents.

Fortunately, their prevalence is lower in children and young adults relative to adults, e.g., post-viral fatigue syndrome, also medically known as myalgic encephalomyelitis.

Moreover, data from studies with adult subjects suggest that despite prolonged duration and persistence of symptoms, post-infection virus syndromes generally resolve within six months or even less, e.g., long COVID.

However, evidence of their pathogenesis and long-term clinical manifestations in the pediatric population is lacking.

An understanding of this is crucial because it represents a considerable healthcare burden with socioeconomic consequences for the patients and their families.

About the study

In the present study, researchers systematically searched multiple databases, such as Google Scholar and Embase, adhering to the PRISMA guidelines to identify relevant studies on post-viral conditions in children.

In this way, they identified randomized controlled trials (RCTs), cross-sectional, observational, cohort, and case-control studies describing post-viral conditions (at least one) in children, adolescents, and young adults, i.e., the population of interest.

The screening process involved an independent assessment of titles, abstracts, and full texts of select studies by four investigators, who resolved disagreements through discussion and assessed the risk of bias in included studies using a quality rating system.

day-to-day tasks, and emergency department (ED) evaluations undertaken.

Results

The authors retrieved 35 studies with data on 42,934 children, adolescents, and adults under 20 who had post-viral infection symptoms.

Of these 35 studies, 28 studies focused on post-COVID conditions, five were on other respiratory viruses, mainly RSV and Rhinovirus, while the remaining two were respectively on EBV and gastrointestinal viruses, namely Adenovirus and Norovirus.

These studies reported both physical and psychological symptoms, with similar symptom duration for post-COVID-19 and post-EBV/gastrointestinal virus syndromes, ranging between 10 days to 18 months.

However, post-acute syndromes after RSV/Rhinovirus infection were of even longer duration (average three years). Post-COVID chronic symptoms occurred among 36.8% of patients within the follow-up time of studies, while 63.2% attained recovery.

Intriguingly, two studies by Kikkenborg Berg et al. showed that the burden of symptoms in patients experiencing Long COVID was comparable to seronegative controls, highlighting a temporal association with infection and not causality.

They evaluated children from zero to 14 years and adolescents from 15 to 18 years in these studies. Further in-depth analysis may help clarify these observations in cases and controls.

As expected, fatigue was a dominant persistent symptom of the post-EBV and post-COVID conditions in older children and adolescents, which likely hindered their everyday tasks and activities.

Another noteworthy symptom shared by both post-COVID and post-gastrointestinal virus syndromes was persistent diarrhea, especially in younger children.

Likewise, studies on RSV and Rhinovirus showed that wheezing was common in children and infants younger than three years.

However, neurocognitive symptoms, such as the lack of concentration and loss of taste and smell, were specific to post-COVID conditions, and even their underlying mechanisms remain unestablished.

Even though data relating to secondary outcomes was scarce, they deserve attention as post-infectious conditions (in general) have a high morbidity burden on the population scale.

Conclusions

Studies have not comprehensively compared the severity and duration of post-COVID symptoms to the symptoms of post-infection syndromes due to other respiratory viruses.

In the present study, the authors found that their symptom duration was similar; however, recovery was achieved in more than half of the children with post-COVID and post-EBV conditions, with a smaller proportion of children developing chronic symptoms.

Future studies should focus on definite age sub-groups and gastrointestinal and cardio-respiratory symptoms for post-viral infection syndromes other than post-COVID.

Other areas worthy of further investigation might be the recurrence rate of symptoms post-recovery, the socioeconomic consequences of these conditions for children and their families, and the comparison of persistent symptoms developed after an asymptomatic acute infection.

Together, these measures could help effectively evaluate pediatric patients experiencing post-COVID or similar conditions and contribute towards preparedness for future pandemics.

Did you subscribe to our daily Newsletter?

It’s Free! Click here to Subscribe!

Source: News Medical

26 COMMENTS

  1. Приветствую! Возник вопрос про займ? Предлагаем безопасный источник финансовой помощи – [url=https://dengizaimy.by/]Dengizaimy[/url]. Вы можете получить средства в долг без избыточных вопросов и документов? Тогда обратитесь к нам! Мы готовы предоставить выгодные условия кредитования, быстрое решение и гарантию конфиденциальности. Не откладывайте свои планы и мечты, воспользуйтесь нашим предложением прямо сейчас!

  2. Здравствуйте! Возник вопрос про займ? Предлагаем безопасный источник финансовой помощи – [url=https://dengizaimy.by/]dengizaimy[/url]. Вы можете получить деньги в долг без избыточных вопросов и документов? Тогда обратитесь к нам! Мы предлагаем выгодные условия кредитования, быстрое решение и гарантию конфиденциальности. Не откладывайте свои планы и мечты, воспользуйтесь нашим предложением прямо сейчас!

  3. Somebody essentially help to make significantly articles Id state This is the first time I frequented your web page and up to now I surprised with the research you made to make this actual post incredible Fantastic job

  4. What i dont understood is in reality how youre now not really a lot more smartlyfavored than you might be now Youre very intelligent You understand therefore significantly in terms of this topic produced me personally believe it from a lot of numerous angles Its like women and men are not interested except it is one thing to accomplish with Woman gaga Your own stuffs outstanding Always care for it up

  5. Wonderful site you have here but I was curious about if you knew of any user discussion forums that cover the same topics talked about here? I’d really love to be a part of community where I can get feedback from other experienced individuals that share the same interest. If you have any suggestions, please let me know. Bless you!
    reviews on reddit mbit casino

  6. zahry machinery equipment llc offers a wide selection of industrial equipment for various applications. We provide reliable solutions to meet the needs of our customers, ensuring their satisfaction with our products and services. Our company is committed to excellence and continuous improvement in everything we do.

    [url=https://miyu-guitar.jp/main01/support02?sid=5328843372494848]Zeolite Heavy Equipment LLC[/url] [url=https://rokochan.org/ai/16819?last100=true#bottom]ZAHRY MACHINERY EQUIPMENT LLC[/url] [url=http://tsolus.com/bbs/board.php?bo_table=online&wr_id=205030]Zeolite Heavy Equip[/url] [url=https://rokochan.org/ai/16559?last100=true#bottom]ZAHRY MACHINERY EQUIPMENT LLC[/url] [url=http://csaladokert.tarsadalmiinnovaciok.hu/forum/topic/earnestrah/?part=2#postid-315500]Zeolite Heavy Equipment LLC[/url] [url=https://fxdailyinfo.com/headway-hears-its-users-personal-area-updated]zeolite heavy equipment llc[/url] [url=http://xn--9v2bp8axyinna.com/bbs/board.php?bo_table=gallery02&wr_id=180870]Zeolite Heavy Equip[/url] [url=https://fxdailyinfo.com/brokers-profile/db-investing]Zeolite Heavy Equipment LLC[/url] [url=http://gorchesterutd.com/forum/viewtopic.php?t=78048]zahry machinery equipment llc[/url] [url=https://isuzuthanhtri.com/product/isuzu-19-tan-nmr85h-euro-4-thung-bat/#comment-226053]zeolite heavy equipment llc[/url] 5b18e6c

  7. Hey, I think your site might be having browser compatibility issues. When I look at your website in Chrome, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, awesome blog!
    casino bitcoins

  8. Thank you a bunch for sharing this with all people you really know what you’re speaking about! Bookmarked. Please also consult with my site =). We can have a hyperlink alternate contract between us
    ricky’s casino

  9. Aviator Spribe играть по стратегии казино
    It that was necessary for me. I Thank you for the help in this question.
    Добро пожаловать в захватывающий мир авиаторов! Aviator – это увлекательная игра, которая позволит вам окунуться в атмосферу боевых действий на небе. Необычные графика и захватывающий сюжет сделают ваше путешествие по воздуху неповторимым.

    Погрузитесь в мир азартного приключения с игрой Aviator Spribe казино играть на евро!
    Aviator игра позволит вам почувствовать себя настоящим пилотом. Вам предстоит совершить невероятные маневры, выполнять сложные задания и сражаться с противниками. Улучшайте свой самолет, чтобы быть готовым к любым ситуациям и становиться настоящим мастером.
    Основные особенности Aviator краш игры:
    1. Реалистичная графика и физика – благодаря передовой графике и реалистичной физике вы почувствуете себя настоящим пилотом.
    2. Разнообразные режимы игры и миссии – в Aviator краш игре вы сможете выбрать различные режимы игры, такие как гонки, симулятор полетов и захватывающие воздушные бои. Кроме того, каждая миссия будет предлагать свои собственные вызовы и задачи.
    3. Улучшение и модернизация самолетов – в игре доступны различные модели самолетов, которые можно покупать и улучшать. Вы сможете устанавливать новое оборудование, улучшать двигательность и мощность своего самолета, а также выбирать различные варианты окраски и декорации.
    Aviator краш игра – это возможность испытать себя в роли авиатора и преодолеть все сложности и опасности воздушного пространства. Почувствуйте настоящую свободу и адреналин в Aviator краш игре онлайн!
    Играйте в «Авиатор» в онлайн-казино Pin-Up
    Aviator краш игра онлайн предлагает увлекательную и захватывающую игровую атмосферу, где вы становитесь настоящим авиатором и сражаетесь с самыми опасными искусственными интеллектами.
    В этой игре вы должны показать свое мастерство и смекалку, чтобы преодолеть сложности многочисленных локаций и уровней. Вам предстоит собирать бонусы, уклоняться от препятствий и сражаться с врагами, используя свои навыки пилотирования и стрельбы.
    Каждый уровень игры Aviator краш имеет свою уникальную атмосферу и задачи. Будьте готовы к неожиданностям, так как вас ждут захватывающие повороты сюжета и сложные испытания. Найдите все пути к победе и станьте настоящим героем авиатором!
    Авиатор игра является прекрасным способом провести время и испытать настоящий адреналиновый разряд. Готовы ли вы стать лучшим авиатором? Не упустите свой шанс и начните играть в Aviator краш прямо сейчас!
    Aviator – играй, сражайся, побеждай!
    Aviator Pin Up (Авиатор Пин Ап ) – игра на деньги онлайн Казахстан
    Aviator игра предлагает увлекательное и захватывающее разнообразие врагов и уровней, которые не оставят равнодушными даже самых требовательных геймеров.
    Враги в Aviator краш игре онлайн представлены в самых разных формах и размерах. Здесь вы встретите группы из маленьких и быстрых врагов, а также огромных боссов с мощным вооружением. Разнообразие врагов позволяет игрокам использовать разные тактики и стратегии для победы.
    Кроме того, Aviator игра предлагает разнообразие уровней сложности. Выберите легкий уровень, чтобы насладиться игровым процессом, или вызовите себе настоящий вызов, выбрав экспертный уровень. Независимо от выбранного уровня сложности, вы получите максимум удовольствия от игры и окунетесь в захватывающий мир авиаторов.
    Играйте в Aviator и наслаждайтесь разнообразием врагов и уровней, которые позволят вам почувствовать себя настоящим авиатором.

  10. Hey there are using WordPress for your site platform? I’m new to the blog world but I’m trying to get started and set up my own. Do you need any coding knowledge to make your own blog? Any help would be greatly appreciated!
    jogar slot starburst

LEAVE A REPLY