- These RBD-specific antibodies are thought to be the most critical for neutralizing the coronavirus, Live Science previously reported.
- Based on the neutralization tests, serum from the breakthrough group was about 950% more potent against the original SARS-CoV-2 virus, compared with controls, the team reported.
- Still, vaccination, alone is protective, even if the combination of vaccination and a breakthrough infection triggers a more potent immune response, Curlin told KATU News.
It’s worth noting that breakthrough cases can still result in lengthy COVID. A new study suggests that catching COVID-19 after vaccination may boost the immune system’s ability to fend off future versions as reported by Live Science.
New variant
The small study only included 26 people with breakthrough infections, and all of the participants had received the Pfizer-BioNTech vaccine, so there’s no data on the other vaccine brands, according to the new research, published Thursday (Dec. 16) in the journal JAMA.
But it does hint that, in general, those who catch COVID-19 post-vaccination may have an edge in fighting off the virus, even if they become exposed to a new coronavirus variant, study co-author Dr Marcel Curlin, an associate professor of medicine at Oregon Health & Science University (OHSU) School of Medicine, told KATU News.
Of course, although this study highlights a potential silver lining to catching a breakthrough infection, contracting COVID-19 after vaccination still carries risks.
For instance, breakthrough infections can lead to long COVID, a syndrome where people experience various symptoms — from debilitating fatigue to cognitive dysfunction to gastrointestinal problems — for many months after their initial COVID-19 infection subsides, Reuters reported.
Mild symptoms
For the study, Curlin and his colleagues collected blood samples from 26 OHSU health care workers, all of whom caught COVID-19 after being fully vaccinated, meaning they’d received two doses of the Pfizer-BioNTech vaccine.
None of the participants had had COVID-19 prior to their breakthrough infections, and 24 of the 26 breakthrough infections caused only “mild symptoms,” the team reported.
The team isolated a clear, yellowish fluid called serum from the blood samples and placed the serum in lab dishes with cultured human cells and SARS-CoV-2, the virus that causes COVID-19.
“Then, using an assessment called a “focus reduction neutralization test,” they determined how effectively the antibodies within the serum neutralized the coronavirus.
When antibodies neutralize a virus, they latch onto the virus in such a way that the bug can no longer infect cells.
Experiments
The team ran experiments with the original strain of SARS-CoV-2 and the alpha, beta, gamma and delta variants of concern, according to the JAMA report.
(They did not run any experiments with the recently-identified omicron variant.)
These experiments revealed that the serum from those with breakthrough infections neutralized the various versions of the virus more effectively than that from the control group.
“So, if I take a person who’s just vaccinated alone, and someone who had vaccine plus breakthrough, and I take their serum and I now stack that up against the alpha variant, or the delta variant, beta … in all cases, the vaccinated infected person has much better able to cope with those other variants regardless of which variant they got infected with,” Curlin told KATU News.
In general, compared with controls, the blood of those with breakthrough infections bore more antibodies that latch onto the receptor-binding domain (RBD) of the virus’s spike protein, which binds directly to the cell surface.
Broaden immune response
Based on the neutralization tests, serum from the breakthrough group was about 950% more potent against the original SARS-CoV-2 virus, compared with controls, the team reported.
Serum from the delta breakthrough infections exhibited higher potency against the variant than serum from the controls or from the non-delta breakthroughs.
This suggests that developing boosters to match different variants could help “broaden” the vaccine-induced immune response, the team noted.
Still, vaccination, alone is protective, even if the combination of vaccination and a breakthrough infection triggers a more potent immune response, Curlin told KATU News.
“What we’re looking at is the exceptional combination of vaccination plus infection,” he said.
Did you subscribe to our newsletter?
It’s free! Click here to subscribe!
Source: Live Science
